敏感性 對熱敏感
密度1.592
熔點 223-224°C
存貯條件 儲存溫度 2-8°C
描述
產品介紹 易溶于熱乙醇，在苯及乙醚中呈黃色，在氨水和硫酸中呈緋紅色，屬蒽醌類化合物，在酸性溶液中被還原則生成蒽酚及其互變異構體的蒽酮。
別名 1,8-二羥基-3-羥甲基蒽醌;蘆薈瀉素;1,8-Dihydroxy-3-(hydroxymethyl)anthraquinone; 3-Hydroxymethylchrysazine
生化機理 Laxative/cathartic compound; increases the contraction of intestinal smooth muscle by releasing endogenous acetylcholine. Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, thus inducing a permeability transition that sets in motion a series of events culminating in cellular apoptosis. Genotoxicity and mutagenicity appear to be due to the inhibition of topoisomerase II activity by aloe emodin.
應用 瀉藥/瀉劑化合物;內源性乙酰膽堿的釋放增加了腸道平滑肌收縮。遺傳毒性和致突變性似乎是由蘆薈大黃素由于抑制拓撲異構酶II活性